维生素E亚油酸酯的合成

Synthesis of Vitamin E Linoleate

以维生素 E、亚油酸和亚硫酰氯为原料合成了维生素 E亚油酸酯 ,用硅胶 (2 0 0～ 30 0目 )作吸附剂 ,石油醚 (6 0～ 90℃ )作洗脱剂进行柱色谱分离纯化 ,得纯品 ,收率 90 .5 % ,含量不小于 97.0 % ,游离维生素 E不大于 3.0 %。并提出一种快速、简易的反应终点控制方法。

Vitamin E linoleate was prepared from vitamin E, linoleic acid and thionyl chloride. The crude ester mixture was purified by using silica gel (200~300 mesh) and petroleum ether (60~90℃) as eluent to give a viscous light yellow pure product (90.5% overall yield), which contained ≥97.0% ester and ≤3.0% free vitamin E. A quick and convenient method was used for controlling esterification end-point.