复合中心对称设计法制备喜树碱非离子表面活性剂囊泡

Camptothecin Niosomes Prepared by Central Composite Design

采用复合中心对称设计法优化喜树碱非离子表面活性剂囊泡的处方和工艺 ,得到的优化条件为 :药物与非离子表面活性剂用量比 1∶ 10 ,非离子表面活性剂与胆固醇用量比 1∶ 0 .6 ,水合搅拌速度 80 0 r/ min,水合温度 5 5°C,5 0 m g药物的分散介质体积 5 0 m

The formulation and process of preparing camptothecin niosomes were optimized by central composite design. The results showed that the optimization conditions were as follows: the ratios of drug to non-ionic surfactant and non-ionic surfactant to cholesterol were 1∶10 and 1∶0.6, respectively; hydration at 55 °C and stirring rate of 800 r/min; dispersion solution volume per 50 mg drug was 50 ml.