期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

尼索地平微球的制备 被引量：5

Preparation of Nisoldipine Microspheres
下载PDF
导出
摘要 采用溶剂挥发法制备了尼索地平微球 ,考察了制备工艺中影响微球质量的 5个主要因素 ,筛选出较理想的处方和工艺。所得微球形态圆整 ,表面光滑 ,粒径 (18.2± 3.8) μm,载药量 2 1.2 % ,包封率 85 .4 %。 The PLGA microspheres loading nisoldipine were prepared by the solvent evaporation method. Several influential variables had been studied and the satisfactory formulation was selected. The nisoldipine microspheres were smooth spheres observed by scanning electron microscope. The mean diameter was (18.2±3.8)μm, the drug-loading ratio was 21.2% and the entrapment efficiency was 85.4%.
作者 李学明 涂家生 张钧寿
机构地区 江苏省武警总队南京医院 中国药科大学药剂教研室
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2003年第10期506-508,536,共4页 Chinese Journal of Pharmaceuticals
关键词 尼索地平 乙交醇丙交酯共聚物 微球 溶剂挥发法 制备工艺 长效控释制剂 钙拮抗剂 nisoldipine poly lactide-co-glycolide(PLGA) microspheres solvent evaporation preparation technics
分类号 R972 [医药卫生—药品] R944.9 [医药卫生—药剂学]
  • 相关文献

参考文献5

  • 1徐超群,廖工铁,张志荣.米托蒽醌聚乳酸缓释毫微粒冻干针剂的体外释药特性研究[J].华西药学杂志,1998,13(4):229-231. 被引量：11
  • 2Patrick B, Ginity JWM. Preparation of microspheres by the solvent evaporation technique[J]. Adv Drug Deliv Rev, 1997, 28:25-42.
  • 3Painbeni T, Venier-Julienne MC, Benoit JP. Internal morphology of poly(D,L-lactide-co-glycolide) BCNU-loaded microspheres. Influence on drug stability[J].Eur J Pharm Biopharm, 1998, 45(1) : 31-39.
  • 4Sanchez A, Vila-Jato JL, Alonso MJ. Development of biodegradable microspheres and nanospheres for the controlled release of cyclosporin A[J]. Int J Pharm,1993, 99(2-3) :263-2?3.
  • 5Gabor F, Ertl B, Wirth M, et al. Ketoprofen-poly(D,L-lactic-co-glycolic acid) microspheres: influenceof manufacturing parameters and type of polymer on the release characteristics[J]. J Microencapsulation,1999, 16(1) :1-12.

二级参考文献2

共引文献10

同被引文献30

  • 1陈镇生.缓释制剂体外溶出考察方法的探讨[J].中国医药工业杂志,1997,28(1):43-47. 被引量：15
  • 2毕殿洲 主编.药剂学[M].北京：人民卫生出版社,2002.321.
  • 3Watts PJ, Davies MC, Melia CD. Microeneapsulation using emulsification solvent evaporation: an overview of techniques and applications[J].Crit Rev Ther Drug Carrier Syst, 1990,7 (3):235-265.
  • 4Guiziou B, Armstrong DJ, Elliott PN, et al. Investigation of in vitro release characteristics of NASID-loaded polylactic acid microspheres[J].J Microencapsul, 1986,13(6) : 701-708.
  • 5Dalbasti T, Karabiyikoglu M, Ozdamar N, et al. Efficacy of controlled-release papaverine pellets in preventing symptom- atic cerebral vasospasm [J]. J Neurosurgery, 2001, 95 ( 1 ) : 44-50.
  • 6Zubkov AY, Rollins KS, McGehee B, et al. Relaxant effect of U0126 in hemolysate-oxyhemoglobin and bloody cerebrospinal fluid-induced contraction in rabbit basilar artery[J].Stroke, 2001,32(1) : 154-161.
  • 7Harley EC Jr, Kassell NF, Tomer JC, et al. A randomized trial of two doses of nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study[J].Neurosurgery, 1994,80(5) : 788-796.
  • 8Sakaki S,Ohue S, Kuwabara H, et al. The role of ventricular and cisternal drainage in the early operation for ruptured intracranial aneurysms[J].Acta Neurochir (Wien), 1987, 88 (3-4) : 87-94.
  • 9Oki S, Kobayashi M, Yoshihara T, et al. Effect of eisternal administration of nicardipine hydrochloride on cerebral vaso- spasm[J]. Hiroshima J Med Sci,1987,36(1) :75-79.
  • 10Pasqualin A, Vollmer DG, Matron JA, et al. Effect of nicar- dipine on vasospasm in rabbit basilar artery after subarach- noid hemorrhage[J].Neurosurgery, 1991,29(2) : 183-188.

引证文献5

二级引证文献14

中国医药工业杂志
2003年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部