血清高密度脂蛋白与脑梗死患者神经功能缺损的关系

Relationship between serum high-density lipoprotein and neurologic impairment in patients with cerebral infarction

目的:分析血清高密度脂蛋白(high-densitylipoprotein,HDL)与脑梗死患者的神经功能缺损及预后等的关系,从而评价临床监测并调控脑梗死患者血清HDL的意义。方法:选择2002-06/2002-12住院并经头颅CT或MRI检查确诊的急性脑梗死患者162例,对照组30例,比较不同类型脑梗死与正常对照组的血清HDL含量,并分析脑血栓形成患者中血清HDL正常组与血清HDL降低组间的病灶大小分布、神经功能缺损程度分布及复发比例、临床疗效间的差异。结果:脑血栓形成组血清HDL含量犤(1.03±0.27)mmol/L犦明显降低,与对照组犤(1.63±0.24)mmol/L犦相比差异有显著性意义(t=10.79,P<0.01),脑血栓形成患者中血清HDL降低组与血清HDL正常组相比,病灶大小及神经功能缺损程度分布差异均有显著性意义(χ2=14.88,P<0.001,χ2=12.59,P<0.01),复发型比例明显增多(χ2=6.35,P<0.05),临床疗效明显差于后者(χ2=5.85,P<0.05)。结论:血清HDL含量降低是脑血栓形成的重要危险因素,且对脑血栓形成患者的神经功能缺损程度、疾病复发及临床疗效有影响,监测脑血栓形成患者的血清HDL水平,并对其进行调控,对改善脑血栓形成患者的神经功能缺损及预后有重要意义。

AIM:To evaluate the significance of monitoring and adjusting serum high-densi ty lipoprotein (HDL) by analyzing the relationship between serum HDL and neurolo gic impairment as well as prognosis in patients with cerebral infarction. METHODS:162 acute cerebral infarction inpatients were diagnosed by CT and MRI from June 2002 to December 2002.The levels of serum HDL were measured and compar ed in 162 patients and 30 normal controls.The differences in the distribution of the size of focus, the degree of neurologic impairment and the recurrence rate of cerebral infarction were analyzed as well as the clinical effect between the decreased serum HDL group and the normal serum HDL group of cerebral thrombosis patients. RESULTS:The level of serum HDL in cerebral thrombosis patients was significant ly lower than the control group (t=10.79,P< 0.01). There was a significant diffe rence in the distribution of the size of focus (,P< 0.001), the degree of neurologic impairment (ral t hrombosis patients.