摘要
目的:观察长期经口摄入铝对大鼠记忆行为的影响及吡拉西坦(商品名:脑复康)的预防作用。方法:Wistar大鼠按体质量随机分为3组,每组10只。Ⅰ组为对照组。每天自由进食及饮水,同时以2mL生理盐水灌胃;Ⅱ组自由进食但饮水中含硫酸铝25g/L(含铝2g/L),同时以2mL生理盐水灌胃。Ⅲ组进食及饮水同Ⅱ组,但每天以50mg吡拉西坦溶于2mL生理盐水中灌胃。3个月后停止生理盐水及吡拉西坦灌胃,继续喂养,应用被动回避实验,观察各组大鼠记忆消退的时间。结果:单纯用硫酸铝大鼠试验后第3周出现记忆消退,3,4,5,6周记忆消失百分数分别为20%,30%,80%,100%;应用吡拉西坦大鼠第3周出现记忆消退,3,4,5,6,7,8,9周记忆消失百分数分别为10%,10%,10%,10%,20%,70%,100%;对照组第7周出现记忆消失,第8周记忆消失百分数达90%,第9周达100%。结论:长期经口摄入铝对大鼠记忆行为有损害作用,吡拉西坦可预防其行为的损害。
AIM: To observe the effect of long-term oral administration of aluminum sulfa te on rat memory behavior and to explore the protective effect of piracetam. METHODS: Thirty Wistar rats were divided into three groups at random,10 for ea ch group.The first group rats had normal food and water freely, with 2 mL normal saline filling stomach;The second and third group rats had normal food and wate r administrated with 25 g/L aluminum sulphate,and the filling stomach fluid was 2 mL normal saline for the second group and 50 mg piracetam in 2 mL normal salin e for the third group.The research on memory in rat with long-term oral adminis tration of aluminum sulfate was studied with passive avoid test after three mont hs.The main measure indexes were the time of memory loss and memory loss percent . RESULTS:Memory loss appeared at 3 weeks in the second group. The percents of m emory loss were 20%, 30%,80%,100%respectively at the third, forth, fifth, si xth week. Memory loss appeared at 3 weeks in the third group. And memory loss pe rcents were 10%, 10%,10%, 10%, 20%,70%, 100%respectively at 3-9 weeks; t he memory loss percents were respectively 10%, 90%, 100%at 7-9 weeks in the first group.
出处
《中国临床康复》
CSCD
2003年第25期3446-3447,共2页
Chinese Journal of Clinical Rehabilitation
关键词
铝
记忆
吡拉西坦
谷氨酸受体
三磷酸肌醇
Long-term oral administration aluminum sulfate has neurotoxic effe ct on rat behaviour and piracetam can be used for protection against its impairm ent.