膀胱移行细胞癌组织中微血管密度与其生物学行为及预后的关系

The relationship between microvessel density derived from transitional cell carcinonma of bladder tissues and its biological behavior and prognosis

目的:通过检测膀胱移行细胞癌组织中微血管密度(MVD),探讨肿瘤新生血管形成与膀胱移行细胞癌发生、发展及预后的关系。方法:应用免疫组织化学技术检测61例膀胱移行细胞癌组织及23例癌旁组织中第Ⅷ因子相关抗原表达,并计数MVD。结果:膀胱癌组织中的MVD明显高于正常膀胱组织,并与膀胱移行细胞癌的分级、分期密切相关(P<0.01.F=25.61,29.72)。肿瘤复发组MVD显著高于无复发组(P<0.01,t=3.20)。膀胱移行细胞癌组织高MVD病例的生存率明显低于低MVD的病例(P<0.05,χ2=26.65)。结论:MVD与膀胱移行细胞癌的发生、发展以及预后密切相关,可作为独立的膀胱移行细胞癌的预后判断指标。

AIM:To investigate the relationship between tumor angiogenesis and the occurre nce ,developing and prognosis of bladder transitional cell carcinonma through de tecting microvessel density derived from bladder transitional cell carcinonma. METHODS:The immunohistochemical method(IHC) were used to measure the expressio n of the Factor VIII related antigen in 61 cases of bladder transitional cell ca rcinoma and 23 cases of adjacent tissues nearby the cancer and MVD was counted. RESULTS:The MVD in bladder transitional cell carcinoma group were much higher than those in the adjacent tissue group, MVD positively related to tumor grades and stages(P< 0.01,F=25.61,29.72).MVD in recurrence cases were significantly hig her than that non-recurrence cases(P< 0.01,t=3.20).The survival ratio of patien ts with high MVD was significantly lower than that of patients with low MVD,χ2= 26.65.