摘要
Objective: To study the immunological mechanisms of Condyloma acuminata(CA) through investigating T lymphocyte subset levels and cytokine profile in the peripheral blood of patients with Condyloma Acuminata.Methods: Tricolor and bicolor immunofluorescent staining antibody of cell surface antigen and intracel-lular IL-2, IL-4, IL-12, IFN- γ in CD4^+ and CD8^+ T-lymphocytes from 20 patients with CA were performed and followed by flow cytometry.Results: The number of CD3^+T, CD4^+T-lymphocytes cells and CD4^+/CD8^+T cells ratio were significantly decreased(P<0.01) in patients with CA Compared to controls, and IL-2, IL-12, IFN- γ production in CD4^+T cells was decreased(P<0.01), IL-4 and IFN- γ produc-tion in CD4^+T cells was not significantly different(P>0.05), while IL-2 and IL-12 production in CD8^+Tc cells was decreased(P<0.01),whereas IFN- γ and IL-4 pro-ducing in CD4^+T cells were of no significantly difference(P>0.05).Conclusions: There was an imbalance of T lympho-cyte subsets, Th1/Th2 cytokines and Tc1/Tc2 in the peripheral blood of CA patients, which may play an important role in the pathogenesis and progression of CA.
