海捷亚治疗轻中度高血压病的临床研究

Effects of hyzaar and plendil on treatment of essential hypertension

目的 研究海捷亚对原发性高血压的降压疗效及安全性 ,并与波依定比较。方法 38例原发性高血压患者 ,随机分为海捷亚组 (2 0例 ) ,波依定组 (18例 ) ,均为口服片剂 ,每天晨服 1次 ,观察 4周 ,每周 1次上午测诊室坐位血压、心率和不良反应。用药前和用药后 4周末检测血液生化指标。结果 两组病例服药 1周后 ,收缩压、舒张压均下降。同自身相对照差异有显著性 (P<0 .0 5 ) ,服药 4周后 ,收缩压、舒张压显著下降 ,同治疗前自身对照差异有显著性 (P<0 .0 1)。海捷亚组和波依定组降压的有效反应率分别为 90 %和 87% ,差异无显著性 (P>0 .0 5 ) ,两组的不良反应率分别为 10 %和 11% ,差异无显著性 (P>0 .0 5 )。海捷亚组治疗 4周后氧化低密度脂蛋白 (ox L DL)较治疗前显著降低 (75± 7)对 (6 5 8± 10 4 ) μg/L(P<0 .0 5 ) ,波依定组治疗前后 ox L DL 无变化 (P>0 .0 5 )。结论 海捷亚和波依定均能达到很好的临床降压效果 ,安全性好 ,不良反应率低 ,海捷亚在降压的同时 。

Objective To observe antihypertensive effect and the safety of hyzaar in essential hypertensive patients.Methods Thirty-eight patients were randomly divided into two groups;20 patients were treated with hyzaar 1 tablet per day for 4 weeks,and another group received plendil 5 mg per day.A sitting BP and HR was measured before and weekly after treatment.Side effects were recorded.Blood biochemical tests were made before and after medication.Results DBP and SBP were reduced at the first week (P<0.05) in both two groups and the reduction at the fourth week was significant (P<0.01=.The total response rate was 90% for hyzaar group and 87% for plendil group (P>0.05),side effect rate was 10% and 11% respectively (P>0.05).The levels of oxLDL of hyzaar group was decreased significantly after treatment (75±7)μg/L vs (66±10)μg/L,P<0.05,there was not change in plendil group before and after treatment.Conclusion Both hyzaar and plendil decreased high BP with safety and less side effects.Besides the antihypertensive effect hyzaar seems to have an antioxidative action.So treatment of hyzaar may have suppressive effect on atherosclerosis.