槲皮素止泻机制研究

Mechanism of quercetin as an antidiarrheal agent

目的研究番石榴叶提取物槲皮素止泻的作用机制。方法观察槲皮素对豚鼠离体回肠收缩活动的影响和对小鼠小肠推进功能的影响,记录其收缩力和推进距离;观察槲皮素对腹腔毛细血管通透性的抑制作用。结果槲皮素抑制离体回肠的收缩,抑制小肠的推进功能,抑制毛细血管的通透性。结论槲皮素能通过抑制肠道的蠕动、抑制肠道毛细血管的通透性来发挥其止泻作用,这也是番石榴叶止泻机制之一。

Objective To investigate the antidiarrheal mechanism of quercetin extracted from Psidium guajava L. Methods The effects of quercetin on the contractility of guinea pig ileum in vitro and on the peristaltic motion of mouse small intestine in vivo were observed, and the peak value of contractility and peristaltic distance recorded. The inhibitory effect of quercetin on the permeability of the abdominal capillaries was also observed. Results Quercetin inhibited the contraction of guinea pig ileum in vitro and the peristaltic motion of mouse small intestine, and reduced the permeability of abdominal capillaries. Conclusion Quercetin can inhibit the intestinal movement and reduce capillary permeability in the abdominal cavity, which may be the antidiarrheal mechanism of Psidium guajava L extract.