有机锗(Ge-132)对糖尿病小鼠血糖影响的初步实验研究

Tentative research of the effect of Ge-132 on blood suger in diabetic rats

目的 :观察有机锗对糖尿病小鼠血糖的影响及其预防效果。方法 :小鼠 2 4只建立糖尿病模型后 ,随机分为高剂量有机锗治疗组 (高剂量组 ) ,低剂量有机锗治疗组 (低剂量组 )和糖尿病未治疗组 (病理对照组 ) ,每组 8只。高剂量组 ,低剂量组分别以有机锗 6 0mg/(kg·d)和 30mg/(kg·d)用水溶解后喂食 ,干预周期 4周 ,测空腹血糖。另 16只小鼠随机分为有机锗预防组 (预防组 )和正常对照组 ,预防组以有机锗 30mg/(kg·d)用水溶解后喂食 ,4周后 ,腹腔注射 (ip)四氧嘧啶 (ALX) ,测空腹血糖。结果 :高剂量组、低剂量组血糖较初均有所下降 ,但与病理对照组比较差异无显著性 (P >0 0 5 ) ;预防组血糖升高较正常对照组血糖升高明显下降 ,且差异有显著性 (P <0 0 5 )。结论 :有机锗对糖尿病小鼠血糖无明显降低作用 。

AIM:To study the effect of Ge-132 on blood sugar in diabetic rats and its preventive effect. METHODS:A total of 40 rats were enrolled in the study, of which, 8 were taken as normal controls, another 8 as preventive group, others, as models of diabetes by injecting Alloxan(ALX) intraabdominal cavityly, were equally divided into three groups: high-dosage group, low-dosage group, and untreated group. After the intervene of Ge-132 for 4 wk, blood sugar in each group was observed. RESULTS:Blood sugar in both high-dosage group and low-dosage group was decreased, but compared with untreated control group, the difference was not so significant (P>0.05). Compared with the normal controls, Ge-132 has significant effect on preventing blood sugar rising in the preventive group (P<0.05). CONCLUSION:Ge-132 has significant effect on preventing blood sugar rising in rats, but its effect on reducing the blood sugar in diabetic rats was not obvious.