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丙型肝炎最新研究动态

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摘要 1 流行病学据估计,全世界约有1.7亿 HCV 感染者,占全球总人口的3%。不同国家间 HCV 感染率有所不同,在0.1%~10%之间。HCV 感染曾是输血后肝炎的主要病原,但在1989年-1992年实施献血员抗-HCV 筛查以来,经输血传播 HCV的危险已大大降低。目前 HCV 感染主要是经皮暴露传播,包括静脉内毒瘾、不规范卫生操作(如血液透析)、针刺(如穿耳孔和纹身)等。HCV 一般不经日常生活接触(如拥抱、接吻和共同进食等)传播。关于 HCV
作者 李奎 庄辉
出处 《传染病信息》 2003年第3期109-113,共5页 Infectious Disease Information
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  • 1Flamm SL. Chronic hepatitis C virus infection. JAMA, 2003, 289:2413- 2417.
  • 2Roberts EA, Yeung L. Maternal - infant transmission of hepatitis C virus infection. Hepatology, 2002, 36(5Suppl 1):S106 - S113.
  • 3El - Serag HB. Hepatocellular carcinoma and hepatitis C in the United States. Hepatology, 2002, 36(5 Suppl 1):S74-S83.
  • 4Varaklioti A, Vassilaki N, Georgopoulou U, et al. Alternate translation occurs within the core coding region of the hepatitis C viral genome. J Biol Chem, 2002, 277:17713- 17721.
  • 5Tseng CT, Klimpet GR. Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J Exp Med, 2002, 195:43-49.
  • 6Crotta S, Stilla A, Wack A, et al. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J Exp Med, 2002, 195:35 -41.
  • 7Griffin SD, Beales LP, Clarke DS, et al. The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine. FEBS Lett, 2003, 535:34-38.
  • 8Pavlovic D, Neville DC, Argaud O, et al. The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. Proc Natl Acad Sci USA, 2003, 100:6104- 6108.
  • 9Egger D, Wolk B, Gosert R, et al. Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex. J Virol, 2002, 76:5974- 5984.
  • 10Bressanelli S, Tomei L, Rey FA, et al. Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides. J Virol, 2002, 76:3482 - 3492.

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