胃癌行全胃切除术后消化道重建术式对营养代谢影响的临床研究

Influence of different procedures of alimentary tract reconstruction after total gastrectomy for gastric cancer on the nutrition and metabolism of patients:a prospective clinical study

目的 从胃癌行全胃切除术后 5种消化道重建术式对营养代谢的影响 ,来探讨最佳的消化道重建的最佳术式。方法 将 14 9例拟行全胃切除的胃癌患者 ,随机抽签法分为 5组 ,每组 30例 (最后一组 2 9例 ) ,消化道重建采用 5种术式。术后 3、6个月检测生活质量指数、预后营养指数PNI ,体重 ,血浆营养学指标 ,作为判断各种术式优劣的依据。结果 5种消化道重建术式对患者的体重 ,生活质量评分、PNI指数及血液营养学指标均有不同程度的影响。Roux en Y组术后体重下降明显 ,且ALB、TP、TF明显低于其他组 ,P <0 0 5 ,差异有显著意义。术后 6个月 ,空肠原位间置代胃术组 ,Hunt Lawrence经十二指肠组 ,HB、SI、TS明显高于Roux en Y组 ,P袢 +Roux en Y组和Hunt Lawrence组 ,P <0 0 5 ,差异有显著意义。结论 全胃切除术后消化道重建术式对患者术后营养有较大影响。有代胃者术后体重恢复较快。空肠原位间置代胃术既有代胃又恢复了十二指肠通道是一种较理想的消化道重建术式。

Objective To investigate the influence of different alimentary tract reconstruction procedures after total gastrectomy for treatment of gastric cancer on nutrition and metabolism and explore an ideal reconstruction procedure Methods A total of 149 patients with gastric cancer who had undergone total gastrectomy were randomly allocated into 5 groups of 30 patients (except the group HLD with 29 cases) to undergo 5 different alimentary tract reconstruction procedures: simple esophagojejunostomy using Roux en Y technique (RY), P pouch with Roux en Y reconstruction (PRY), jejunal pouch reconstruction according to Hunt Lawrence technique (HL), jejunal pouch original interposition reconstruction modified by the authors (JOP), and Hunt Lawrence reconstruction technique maintaining duodenal passage (HLD) Three and six months after operation, quality of life (Visick grade), PNI; body weight; and serum nutritional parameters, including albumin, (ALB), total protein (TP), transferrin (TF), hemoglobin (HB), and serum iron (SI), were evaluated Results In comparison with those of the PRY, HL, JOP, and HLD groups, the patients of the RY group show greater weigh loss, and lower ALB, TP, and TF (all P <0 05). The HB, SI, and TS levels in the JOP group and HLD group were significantly higher than those in the RY, PRY, and HL groups (all P <0 05) Conclusion Different procedures of alimentary tract reconstruction after total gastrectomy have great influence on the patients′ nutrition at different degrees The patients undergoing the procedures with a reservoir show higher serum nutritional parameters and better body weight The volume of reservoir has no major clinical importance The jejunal pouch original interposition reconstruction modified by the authors (JOP), constructing a gastric reservoir and maintaining the alimentary tract flowing through the duodenum is an ideal choice for the reconstruction after total gastrectomy