摘要
目的:研究雷贝拉唑对消化溃疡患者夜间酸突破(NAB)及夜间碱化波(NAKA)的影响。方法:开放、对照研究。活动期消化性溃疡病人40例,随机分为3组,分别给予雷贝拉唑(RAB)10mg(n=15)、奥美拉唑(OME)20mg(n=15)及泮托拉唑(PAN)40mg(n=10)单剂量口服,健康对照组20例,不服安慰剂,监测24h胃内pH。结果:RAB组NAB的pH均值(1.84±0.55)大于OME(1.15±0.31)及PAN(1.10±0.30)(P均<0.01);RAB组NAKA的持续时间(4.65±1.22)h较OME组(3.22±1.89)h及PAN组(3.15±1.92)h明显延长(P均<0.05),也明显高于健康对照组(P<0.01);同时,NAKA均值在RAB组pH(6.41±0.45)较PAN组(6.01±0.92)高,差异有显著性(P<0.05)。结论:RAB10mg单剂量口服能提高NAB的pH、缩短NAB时间、提高NAKA的pH及延长NAKA的持续时间。
Objective: To study the effects of rabeprazole (RAB) on nocturnal acid breakthrough (NAB) and nocturnal alkaline amplitude(NAKA)and compare it with that of omeprazole(OME) and of pantoprazole(PAN). Method:By an open,comparative study, forty patients with active peptic ulcer were randomly assigned to receive one of the three PPI once orally(RAB 10mg,OME 20mg or RAN 40mg). Twenty healthy volunteers served as control group. Intragastric pH monitoring were performed Ihour before and 24 hours after dosing. Result:(1)The intragastric pH of NAB group was significantly higher in RAB group than those in OME group(1.15±0. 31)and PAN group (1. 10±0. 30)(both P<0. 01); (2)RAB produced on NAKA not only a longer sustaining time(4. 65±1. 22)comparing with OME(3.22±1.89) (P<0. 05) ,PAN(3. 15±1. 92) (P<0. 05)and the control group(P<0.01),but also a much higher pH on NAKA (6. 41±0. 45)comparing with PAN(6. 01±0. 92), there was a significance(P<0. 05). Conclusion: A single dose of RAB 10mg orally can increase the pH of NAB and shorten the sustaining time of NAB;in addition,it can increase the pH of NAKA and prolong the sustaining time of NAKA.
