奥氮平对体重、肝功能、血糖、血胆固醇水平的影响

The effects of olanzapine on body weight, liver functions, blood sugar and cholesterol level

目的:回顾性调查奥氮平对患者体重、肝功能、血糖、血胆固醇水平的影响。方法:87例奥氮平治疗至少6周的精神分裂症患者,比较治疗前后体重、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(T-Bil)、血糖(GLU)、血胆固醇(CHO)的变化。结果:治疗6周后患者体重明显增加,平均增加2.2kg,与基线相比具有显著性差异(P<0.001)。治疗后ALT,AST和CHO水平也明显高于基线值,具有显著性差异(P<0.01)。但治疗后T-Bil水平降低,与基线相比差异具有显著性(P=0.026)。治疗前后血糖无显著差异(P=0.882)。体重的变化与年龄和基线体重呈负相关,相关系数分别为-0.33和-0.32(P=0.003和0.004)。ALT及AST的变化与治疗6周后的体重变化呈正相关,相关系数分别为0.34和0.40(P=0.024和0.007)。结论:奥氮平引起患者体重增加、无症状性转氨酶升高和CHO升高。

Objective:To investigate retrospectively the effects of olanzapine on body weight, liver functions,blood sugar and cholesterol level. Methods:87 patients with schizophrenia have been received olanzapine treatment for at least 6 weeks. The pre- and post-treatment data on their body weight,liver functions,blood sugar and cholesterol levels were compared. Results: Their body weights were obviously increased after treatment, with an average increase of 2. 2kg, and there were significant difference in comparison with baseline data. In comparison with baseline data,their post-treatment data on ALT,AST and CHO (blood cholesterol) were significantly increased (P<0.01) but T-Bil (total bilirubin) was significantly decreased (P = 0. 026) and no GLU level change was observed. Conclusion : The 6 weeks treatment of olanzapine affected the body weight, liver functions and blood cholesterol level of the patients.