无创双相气道正压通气治疗急性心源性肺水肿的研究

The Study on the Treatment of Acute Cardiogenic Pulmonary Edema by Noninvasive Bilevel Positive Sirway Pressure Ventilation

目的 研究无创鼻面罩双相气道正压通气 (BiPAP)治疗急性心源性肺水肿 (ACPE)的临床价值 .方法 对4 0例已严重缺氧的ACPE患者应用无创鼻面罩BiPAP治疗 ,观察心率、呼吸频率、血氧饱和度 (SpO2 )、血气分析和心功能等变化 .结果 鼻面罩BiPAP治疗 2～ 5h后 ,心率和呼吸频率明显减慢 (p <0 .0 0 1)、PaO2 和SpO2 明显提高(p <0 .0 0 1)、PaCO2 改变不明显 (p >0 .0 5 )、心功能明显改善 (p <0 .0 0 1) .

Objective To evaluate the clinical application of noninvasive nasal mask bilevel positive airway pressure (BiPAP) ventilation in the treatment of acute cardiogenic pulmonary edema. Methods Forty patients with acute cardiogenic pulmonary edema(ACPE) were treated with noninvasive nasal mask BiPAP ventilation. Before and after ventilatory support, the heart rate and breathing rate, SpO 2, PaO 2, PaCO 2 and heart function were recorded.Results After 2～5 hours treatment,the heart rate and breathing rate were significantly reduced (p<0.001). SpO 2 and PaO 2 were markedly increased(p<0.001). PaCO 2 was not changed very much(p>0.05). All patients' heart function was markedly improved.Conclusions The noninvasive nasal mask BiPAP is a kind of safe and effective method in the treatment of ACPE. It can be recommended for clinical use.