阿卡波糖对糖耐量低减患者胰岛细胞功能和胰岛素敏感性的影响
摘要
目的 探讨阿卡波糖对糖耐量低减 (IGT)患者胰岛细胞功能和胰岛素敏感性的影响。方法 5 0例确诊IGT患者随机平分为阿卡波糖干预治疗的观察组和单纯生活方式控制的对照组。观察患者反映机体胰岛素抵抗程度的HOMA -IR指数和反映胰岛细胞功能的胰岛早期分泌功能指数 (ESSI)的变化。结果 与单纯生活方式干预的对照组相比 ,观察组服用阿卡波糖 3个月后 ,餐后血糖、空腹和餐后 2h血清胰岛素、C肽、血清甘油三酯、HOMA -IR指数和ESSI指数明显低于前者。与服用阿卡波糖前相比 ,观察组的上述指标也有明显降低。
出处
《广东医学》
CAS
CSCD
2003年第11期1217-1219,共3页
Guangdong Medical Journal
参考文献7
-
1Li G, Hu Y, Yang W, et al. Effects of insulin resistance and insulin secrtoon on the efficacy of intervention to retard development of type 2 diabetes mellitus: the DA Qing IGT and Diabetes Study. Diabetes Res Clin Praet,2002,58(3):193.
-
2Kitaoka H. Effocacu of combination therapy of alpha - glucosodase inhobotor and insulin sensitizer in patients with type 2 diabetes. Nippon Rinsho, 2002,60(Suppl 9):464.
-
3Haffner SM, Mykkanen L, Festa A, el al. Insulin - resistant prediabetic subjects have more aterogenic risk factors than insulin - sensitive prediabetic subjects. Circulation,2000,101:975.
-
4Edelstein SL, Knowter WC, Bain BP, et al. Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies.Diabetes, 1997,46(4) :701.
-
5Haffner SM. Can redudng peaks prevent type 2 diabetes: implication from recent diabetes prevention trials. Int J Clin Pract Suppl,2002,129:33.
-
6Knowter WC, Barrett E, Foxier SE, et al. Reduction in the incidence of type2 diabetes with life style intervention or metformin. N Engl J Med,2002,346(6) :393.
-
7Chiasson JL, Gomis R, Hanefeld M. The STOP- NIDDM: an international study on the efficacy of an alpha - glucosidase inhibitor to prevent type 2 diabetes in a population with impaired glucose tolerance: rationale, design, and preliminary screening data. Diabetes Care, 1998,21(10):1720.
-
1王丽丽.肺栓塞患者血小板活化指标的变化研究[J].中国医药指南,2016,14(4):98-98. 被引量:1
-
2韩仰东,韩燕,何旺.糖耐量低减患者血清瘦素与胰岛素抵抗的关系及罗格列酮的干预作用[J].西北药学杂志,2009,24(6):493-494. 被引量:3
-
3血脂正常是否可以考虑停药?[J].健康指南(中老年),2016,0(10):68-68.
-
4陆祖谦,池建昌,张星哲.生活方式控制下基础胰岛素的应用[J].药品评价,2011,8(15):52-55.
-
5王墨华.二甲双胍干预治疗代谢综合征的疗效[J].心理医生(下),2011(6):180-180.
-
6李晨钟,薛耀明,高方.格列吡嗪控释片对2型糖尿病患者胰岛细胞功能和胰岛素敏感性的影响[J].广东医学,2004,25(6):719-720.
-
7张文发,李爱娇.拜唐苹治疗糖耐量低减患者临床观察[J].江西医药,2002,37(6):444-445. 被引量:2
-
8宋长祥.苯那普利对老年高血压病伴糖耐量低减作用探讨[J].淮海医药,2002,20(6):469-470.
-
9程言博,周延龙,董艳,李新华,葛巍,汪莉萍,董瑞国.ESAT-6诱导的外周血单个核细胞γ-干扰素反应对结核性脑膜炎的诊断价值[J].徐州医学院学报,2012,32(7):448-450. 被引量:2
-
10郝齐志.拜唐苹对糖耐量低减患者疗效观察[J].医药论坛杂志,2004,25(8):54-54. 被引量:2