前列腺素E_1联合丹参治疗肝纤维化80例疗效分析

TTHERAPEUTIC ANALYSIS OF COMBINED TREATMENT OF 80 CASES OF HEPATIC FIBROSIS WITH PROSTAGLANDIN E1 AND INJECTION OF RADIX SALVIAE MILTIORRHIZAE

目的 探讨前列腺素素E_1(PGE_1)联合丹参注射液治疗慢性乙肝及代偿性肝硬化肝纤维化的临床疗效。方法 210例慢性乙肝及代偿性肝硬化肝纤维化患者被随机分为联合组(PGE_1联合丹参治疗)80例,丹参组(单用丹参治疗)80例及对照组50例,分别观察治疗前后血清HA、LN、PCⅢ、Ⅳ-C水平,临床症状体征及肝功能等指标的变化。结果 治疗结束后,联合治疗组血清HA、LN、PCⅢ、Ⅳ-C等肝纤维化指标下降最明显,优于丹参组及对照组(P<0.01或P<0.05);肝功能指标AST、TBiL、A/G复常率与对照组比较差异显著(P<0.01)。结论 PGE_1联合丹参治疗慢性乙肝可有效改善肝功能,减轻和抑制肝纤维化的发生。

Objective To explore the clinical effects of the combined treatment of compensatory hepatic fibro-sis with prostaglandin E1(PGE1) and injection of Radix Salviae Miltiorrhizae. Methods 210 cases of chronic hepatitis B and compensatory hepatic fibrosis were randomly divided into the combined treatment group with 80 cases treated with prostaglandin El and injection of Radix Salviae Miltiorrhizae, the group with 80 cases treated only with injection of Radix Salviae Miltiorrhizae and the contrast group with 50 cases. The changes of the serum levels of HA, LN, PC III, IV ~ C, the clinical physical signs and the liver functions before and after the treatment were observed respectively. Results The levels of serum HA,LN,PC III and IV -C were found obviously lowered in the combined treatment group in contrast to other two groups(P<0.01 or P <0.05). The improvement rates of such liver functional indexes as AST,TBIL and A/G in the combined treatment group were significantly different from those of the contrast group(P<0.01). Conclusion The combined treatment of chronic hepatitis B with PGE1 and injection of Radix Salviae Miltiorrhizae can effectively improve liver functions,relieve and suppress hepatic fibrosis.