α-干扰素治疗毛细支气管炎104例疗效分析

THERAPEUTIC ANALYSIS OF INTERFERON α - 2b IN TREATING 104 CASES of BROCHIOLITIS

目的 探讨治疗毛细支气管炎的有效方法。方法 将190例呼吸道合胞病毒(RSV)所致毛细支气管炎住院患儿,随机分为A(104例)、B(86例)两组,分别用基因重组干扰素α-2b(rIFNα-2b)和布地奈德(BUD)治疗。结果 用rIFNα-2b治疗的A组患儿入院后病程及咳嗽、憋喘等主要症状和体征的缓解或消失所需时间显著少于用BUD治疗的B组(P<0.05),且无不良反应。结论 使用rIFNα-2b治疗毛细支气管炎的疗效好,并能避免使用皮质激素产生的副作用。

Objective To explore an effective therapy of treating bronchiolitis. Methods 190 cases of bronchi-olitb caused by respiratory syncytical virus were randomly divided into Group A (104 cases) and Group B (86 cases) which were treated with interferon α-2b and budesonide respectively. Results The time of remission or disappearance of such physical signs as cough and asthma in Group A was found much less than that in Group B ( P <0.05). No side effects were found in Group A. Conclusion Good curative effects can be obtained by use of interferon α-2b and side effects caused by cortical hormone can be avoided in this way.