前胡咳痰汤药理作用研究

Studies on The Pharmacological Effect of Qianhu Ketan Tang

目的 :探讨前胡咳痰汤的药理作用。方法 :分别用氨水及组胺与乙酰胆碱吸入造成小鼠咳嗽与哮喘的模型 ,给予前胡咳痰汤及阳性对照药进行治疗 ,利用酚红腹腔注射观察其祛痰作用。以流感病毒滴鼻法造成模型 ,观察了本方的抗病毒作用。结果 :1前胡咳痰汤大、小剂量组均能明显延长小鼠咳嗽潜伏期。 2本方的大剂量组酚红排泌量高于空白对照组。 3本方大剂量组引喘潜伏期较空白对照组明显延长 ,大剂量组较氨茶碱组引喘潜伏期稍有延长。 4前胡咳痰汤大剂量组肺指数比病毒组减轻。结论 :前胡咳痰汤有明显的止咳 ,化痰 ,平喘及抗病毒作用。

Objective:To explore the pharmacological effect of Qianhu Ketan Tang(QKT).Methods:Mouse model of cough and model of asthma were established by using ammonia and histamine with acetycholine inspiration accordingly. We investigated effects of OKT and a positive drug on expectorant by using the model with intraperitoneal injection of phenolsulfonphthalein. The anti-virus action of QKT was evaluated by a model of virus infection induced by influenzavirus nosedrop.Results:1 QKT high dose group and QKT low dose group can prolong the cough incubation period in mice. 2 QKT high dose group can increase the excretion of phenolsulfonphthalein. 3 QKT high dose group can prolong the sathma incubation period in mice. 4 The lung weights of QKT high dose group are lower than that of model group. Conclusion:QKT have good effect of cough suppression, expectorant and relieving asthma, and it can protect lung from attack of virus.