沙苑子提取物调脂和保肝作用的实验研究

Experimental Study of Semen Astragali Complanati Extract on the Lipid-Modifying and Liver-Protective Effects

目的 :观察沙苑子提取物A和B的调脂和保肝作用。方法 :将雄性大鼠给脂肪乳剂造成高脂模型 ,在连续给予沙苑子提取物 2 0d后 ,观察血清中TC、TG、LDL C、HDL C和肝重量系数的变化。雄性小鼠给沙苑子提取物 14d后腹腔注射 0 0 7%四氯化碳 0 1ml 10g ,然后观察血清中ALT和AST的变化。结果 :给予沙苑子提取物A和B后 ,均可降低高血脂大鼠血清TC、TG和LDL C ,升高LDL C ,四氯化碳肝损小鼠的血清ALT和AST也均明显下降。结论 :沙苑子提取物A和B均具有明显的调脂和保肝作用。

Objective:To observe the lipid-modifying and liver-protective effects of semen astragali complanati extract A and B.Methods:Male hyperlipidemic rats were induced by feeding with fat milk.The serum TC,TG,HDL-C,LDL-C and coefficient of hepatic weight were measured after administration of semen astragali complanati extract for 20 days.The levels of serum ALT and AST of the mice injured by ip 0.07% CCl 4 0.1ml/10g were examined after mice were given semen astragali complanatix extract for 14 days.Results:In semen astragali complanati extract A and B groups,the levels of serum TC,TG and LDL-C were lower than those in the hyperlipidemic group,while serum HDL-C was increased.The serum ALT and AST levels in semen astragali complanati extract groups were lower than those in liver-injured group as well.Conclusion:Semen astragali complanati extract A and B possessed the obvious lipid-modifying and liver-protective effects,and the effects of both extracts were basically similar.