p27kip1及p53基因蛋白与恶性卵巢上皮性肿瘤预后的关系

Relationship between the expression of p27kip1 and p53 gene protein and the prognosis of epithelial ovarian carcinoma

目的 探讨 p2 7kip1和 p5 3基因蛋白在恶性卵巢上皮性肿瘤中的表达及其与预后的关系。 方法 1992年 11月至 1999年 12月应用免疫组化检测 5 6例恶性卵巢上皮性肿瘤石蜡切片中 p2 7kip1和p5 3基因蛋白表达情况 ,并应用Kaplan -Mier法及多变量Cox比例风险回归模型分析患者预后。 结果 5 6例恶性卵巢上皮性肿瘤患者的 p2 7kip1基因蛋白表达率为 4 1 1% ;p5 3基因蛋白表达率为 4 8 2 % ,两种基因蛋白表达比较 ,差异无显著性 (P >0 0 5 )。p2 7kip1及 p5 3基因蛋白表达与肿瘤的病理分级有关 ( P <0 0 5 ) ,与其他临床病理特征无关。单因素分析 :p2 7kip1及 p5 3基因蛋白表达与患者的中位生存时间、生存曲线各时点生存率密切相关。 结论 p2 7kip1基因蛋白表达对恶性卵巢上皮性肿瘤的预后有显著影响 ,而 p5

Objective To study the expression of p27kip1 and p53 protein in epithelial ovarian carcinoma(EOC)and its relation to the prognosis.Methods From November 1992 to December 1999,expression of p27kip1 and p53 proteins was retrospectively studied by immunohistochemistry;and Kaplan Meier method and Cox's proportional hazard regression model were used to analyze the relation between their expressions and prognosis.Results The expression rates of p27kip1 and p53 protein in 56 epithelial ovarian carcinoma were 41\^1% and 48\^2%,respectively.There was no significant difference in the expression of these two proteins(P>0\^05).Expression of the two proteins was correlated with tumor grade(P<0\^05),but not with other clinical pathological features.In univariate analysis,expression of p27kip1 and p53 was closely related with median survival time and survival rates in survival curve(P<0\^05).Conclusion The expression of p27kip1 is an independent prognostic factor in EOC.There is no significant correlation between the over expression of p53 protein and the prognosis of the patients with EOC.