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聚乙二醇化干扰素及其联合病毒唑的不良反应 被引量:20

Adverse effcts of combining polyethylene glycol interferon with ribavilin on hepatitis C patients.
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摘要 聚乙二醇化干扰素(pegylated interferon,peg干扰素)因其与聚乙二醇(PEG)结合成大分子物质,从肾脏排泄慢,半衰期明显延长,较标准干扰素延长约6~10倍.
作者 斯崇文
出处 《中华肝脏病杂志》 CAS CSCD 2003年第11期686-687,共2页 Chinese Journal of Hepatology
关键词 聚乙二醇化干扰素 联合用药 病毒唑 不良反应 利巴韦林 病毒性肝炎 Interferon a2a Hepatitis C Therapeutics Intoxication Ribavilin
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参考文献7

  • 1Fried MW, Schiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for patients with chronic hepatitis C virus infection. N Engl J Med, 2002, 347: 975-982.
  • 2Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet,2001, 358: 958-965.
  • 3Russo MW, Fried MW. Side effects of therapy for chronic hepatitis C. Gastroenterology, 2003, 124: 1711-1719.
  • 4DE Franceschi L, Fattovich G, Turrini F, et al. Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis c virus infection:role of membrane oxidative damage. Hepatology,2000, 31: 997-1004.
  • 5Shiffman ML,Hofmann CM, Luketic VA, et al. Use of granulocyte macrophage colony stimulating factor alone or in combination with interferon-alfa-2b for treatment of chronic hepatitis C. J Hepatology,1998, 28:382-389.
  • 6Pockros PJ, Duchini A, McMillar R, et al. Immune thrombocytopenic purpura in patients with chronic hepatitis C virus infection.Am J Gastroenterol, 2002, 97: 2040-2045.
  • 7Deutsch M, Dourakis S, Manesis EK, et al. Thyroid abnormalities in chronic viral hepatitis and their relationship to interferon alfa therapy. Hepatology, 1997, 26: 206-210.

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