武汉市2002年新发肺癌病人主要危险因素研究

A Case-control Study on Main Risk Factors of Newly Diagnosed Lung Cancer in Wuhan in 2002

[目的]了解武汉市肺癌危险因素的现状及其变化规律。[方法]采用1∶1配对病例对照和Logistic回归分析方法,对武汉市2002年209例新发肺癌病人进行调查和分析,并与1995年的调查结果进行比较。[结果]多因素条件Logistic分析表明,武汉市新发肺癌病人的主要危险因素依次为:吸烟、慢性支气管炎病史、人均月收入低、精神压抑和住地附近有污染源,其调整比值比及95%可信区间(OR及95%CI)分别为4.263(2.214～8.211)、3.832(1.722～8.527)、2.288(1.268～4.130)、2.162(1.034～4.522)、1.827(1.106～3.017)。[结论]1995年以来,武汉市人群肺癌发生的主要危险因素没有太大的变化,主要为吸烟、住宅内外环境污染和精神因素。但是,某些因素似乎变得相对集中和明显,如吸烟的OR(95%CI)由2.71(1.70～4.34)上升到4.263(2.214～8.211)。提示,要深入研究吸烟、精神因素对肺癌发病的影响,为武汉市地方性防治措施的制订提供科学的依据。

[Purpose]To evaluate and update the evidence on the risk factors of lung cancer in Wuhan.A hospital-based,1∶1matched case control study was conducted during2002in Wuhan.Two hundred and nine newly diagnosed primary lung cancer cases and equal number of control,matched for age and sex,were enrolled and interviewed.Multivariate conditional Logistic regression analysis showed5main risk factors for lung cancer in Wuhan population.The order of the main risk factors was as follows:smoking with odds ratio(OR)4.263(95%CI2.214～8.211),history of chronic bronchitis with OR3.832(95%CI1.722～8.527),low income with OR2.288(95%CI1.268～4.130),psy-chological repression with OR2.162(95%CI1.034～4.522)and air pollution near the residence with OR1.827(95%CI1.106～3.017).[Conclusion]Compared the result from this study with that from1995,the main risk factors of lung cancer in Wuhan including smoking,air pollution inside and outside the house and psychosis factor keep stabilization.But there is an increased risk for lung cancer from cigarette smoking in this study compared with data reported by the study in1995.The OR for smoking increased from2.71(1.70～4.34)to4.263(2.214～8.211)in2002.It is concluded that further studied on the smoking and psychosis factors should be conducted to provide scientific foundation for making re-gional preventive measures for lung cancer.