神经干细胞及其在神经系统疾病中的应用前景
被引量:1
Neuronal Stem Cell and Its Prospect of Application in Diseases of Nervous System
摘要
长期以来,人们认为中枢神经系统神经元在个体出生前业已完成,之后不具有再生能力.20世纪90年代初期,研究者在成年啮齿类动物及人的脑和脊髓中分离出能够不断分裂增殖,在特定条件下,具有向神经元、神经胶质细胞分化潜能的原始细胞,并在体外培养成功,提出了神经干细胞(neuronal stem cell)的概念[1].
出处
《中国微循环》
2003年第5期329-332,共4页
Journal of Chinese Microcirculation
参考文献32
-
1Temple S.The development of neural stem cells[J] .Nature. 2001,414 (6859) :112- 117.
-
2Romero-Ramos M, Vourc'h P, Young HE, et al. Neunmal differentiation of stem cells isolated from adult muscle[ J ]. J Neurosci Res. 2002,69( 6):894-907.
-
3Andressen C, Stocker E, Klinz FJ, et al. Nestin-specific green fluorescent rotein expression in embryonic stem cell-derived neural precursor cells used for transplanation[J]. Stem Cells. 2001,19(5) :419 - 424.
-
4Johansson CB, Momma S, Clarke DL, et al. Identification of a neural stem cell in the adult mammalian central nervous system[J]. Cell. 1999,96(1) :25-34.
-
5Vescovi AL, Parati EA, Gritti A, et al. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation [J ].Exp Ncurol. 1999,156(1) :71 - 83.
-
6Cicoollni F, Svendsen CN. Fibroblast growth factor 2(FGF- 2) promotes acquisition of epidermal growth factor(EGF) responsiveness in mouse striatal precursor cells: Identification of neural precursors responding to both EGF and FGE - 2[J] .J Neurosci. 1998,18(19) :7869- 7880.
-
7Takahashi J, Palmer TD, Gage FH. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures[J]. J Neurobiol. 1999,38:65- 81.
-
8Johe KK, Hazel TG, Muller T, et al. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system[J]. Genes Dev.1996, 10(24) :3129- 3140.
-
9Okano H. Stem cell biology of the central nervous system [J]. J Neurosci Res. 2002,69(6) :698 - 707.
-
10Gage FH, Coates PW, Palmer TD, et al. Survival and differentiation of adult neuronal progenitor cells transplaned to the adult brain[J]. Proc Natl Acad Sci USA. 1995(6) ,92: 11879- 11883.
同被引文献10
-
1万小凤,赵小立,张铭.胚胎干细胞体外分化为多巴胺能神经元[J].细胞生物学杂志,2004,26(5):450-454. 被引量:1
-
2陈丽.神经干细胞在神经内科疾病中的应用(综述)[J].中国城乡企业卫生,2004,19(6):28-28. 被引量:1
-
3Petersen MC, Palmer FB; Advances in prevention and treatment of cerebral palsy. Merit Retard Dev Disabil Res Rev,2001.
-
4Sreenan C, Bbargava R, Charlene MT, et al. Crebral in farction in the term newborn; Clirucial Presentation and long-term outcome; Pediatr,2000.
-
5程相文,李日光.人类基因图与医药学创新[J].海南医学,2002,13(1):88-89. 被引量:2
-
6王飞,黄强.神经干细胞与脑胶质瘤的治疗[J].中国肿瘤,2003,12(1):21-23. 被引量:2
-
7杨忠旭,栾国明.神经干细胞的增殖分化及在癫痫治疗中的应用[J].实用临床医药杂志,2003,7(3):215-217. 被引量:3
-
8王飞,黄强.成体神经干细胞的研究进展及应用前景[J].卒中与神经疾病,2003,10(4):253-255. 被引量:5
-
9王飞,李世亭,潘庆刚.神经干细胞定向诱导分化为神经元的研究进展[J].同济大学学报(医学版),2004,25(2):168-170. 被引量:3
-
10顾文佳,庞希宁.诱导胚胎干细胞向神经细胞分化方法的研究与探讨[J].细胞生物学杂志,2004,26(2):145-148. 被引量:5
-
1任映茜,杨建中,路顺义.A型肉毒毒素局部注射注意事项[J].临床医药实践,2004,13(12):953-953.
-
2张林会,赵宗茂.干细胞移植治疗中枢神经系统疾病的研究进展[J].临床荟萃,2011,26(12):1096-1098.
-
3郑昌成,王祖贻.急性淋巴细胞白血病脑脊液原始细胞及损伤性腰穿对预后的影响[J].国外医学(输血及血液学分册),2004,27(5):417-419.
-
4储丹晨,韩辉,谢道俊,吴丽敏,韩明向.中药复方对缺血性卒中后神经再生影响的研究进展[J].中医药临床杂志,2012,24(11):1086-1088. 被引量:3
-
5崔元孝,于兆昂,田敏,张清华.神经干细胞移植治疗脑出血的研究[J].中国医师进修杂志,2009,32(10):74-75. 被引量:1
-
6李俐娟,张苏明.干细胞移植治疗脑血管疾病的研究进展[J].华中医学杂志,2006,30(3):211-212.
-
7刘红娟,汪青松.骨髓干细胞移植治疗脑梗死的进展[J].安徽医科大学学报,2011,46(12):1292-1295. 被引量:1
-
8田轶,汤永红.干细胞移植在脑出血和脑梗死治疗中的应用研究[J].社区医学杂志,2012,10(23):15-17.
-
9韩肖华,黄晓琳.神经干细胞治疗缺血性脑卒中的研究进展[J].中国康复,2009,24(3):202-204.
-
10庞源广,袁琼兰.神经干细胞移植在缺血性脑损伤治疗中的应用[J].同济大学学报(医学版),2010,31(2):117-120. 被引量:9