1[1]Hall lC, O'Toole E. lntestinal flora in new-bom infants:with a description of a new pathogenic anaerobe, Bacillus difficilis. Am J Dis Child, 1995,49(2):390-402.
2[2]Bartlett JG, Chang TW, Gurwith M, et al. Antibiotic-associated pseudomemhranous colitis due to toxin-producing clostridia. N Engl J Med1978,298(10) :531-534.
3[3]Buchner AM, Sonnenberg A. Epidemiology of clostridium difficile infection in a large population of hospitalized US military veterans. Dig Dis Sci,2002,47(1) :201-207.
4[4]Kelly CP, LaMont JT. Clostridium difficile infection, Annu Rev Med 1998,49: 375-390.
5[5]Shim JK, Johnson S, Samore MH, et al. Primary symptomless colonisation by clostridium difficile and decreased risk of subsequent diarrhoea. Lancet 1998,351 (9103 ): 633-636.
6[6]Spigaglia P, Mastrantinio P. Molecular Analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcaC) among clostridium difficile. J clin Microbiol 2002, 40(9): 3470-7475.
7[7]He D, Sougioutzis S, Hagen S, et al. Clostridium difficile toxin A triggers human calonocyte lL-8 release via mitochondrial oxgen radical generation. Gastroenterology,2002,122(4): 1048-1057.
8[8]Chen ML, Pothoulakis C, LaMont JT. Protein kinase C signaling requlates ZO-1 transloeation and increased paracellular flux of T84 colonocytes exposed to clostridium difficile toxin A. J Biol Chem 2002,277(6):4247-4254.
9[9]Kyne L, Warny M, Qamar A, et al. Asymptematic carriage of clostridium difficile and serum levels of lgG antibody against toxin A. N Engl J Med, 2000,342(6): 390-397.
10[10]Moyenuddin M, Williamson Jc Ohl cA. Clostridium difficile-associated diarrhea: curent stracegies for diagnosis. Curr Gastroenterol Rep, 2002,4 (4):279-286.
9Vonberg RP, Kuijper EJ, Wilcox MH, et al. Infection control measures to limit the spread of Clostridium difficile [ J]. Clin Microbiol Infect, 2008, 14( Suppl 5) :2-20.
10Kuijper E J, Coignard B, Tull P. Emergence of Clostridium difficile-associated disease in North America and Europe [ J ]. Clin Microbiol Infect, 2006, 12 ( Suppl 6) :2-18.
