甘草酸两种异构体治疗肾综合征出血热的疗效观察

Clinical Observation of the Effects of Two Glycyrrhizic Acid Isomates in Treatment of Hemorrhagic Fever with Renal Syndrome

目的 :比较甘草酸两种异构体治疗肾综合征出血热 (HFRS)的临床效果。方法 :HFRS患者78例 ,随机分为A、B两组。A组加用甘草酸α体制剂 (甘利欣 )静脉滴注 ,B组加用甘草酸β 体制剂 (美能 )静脉滴注。观察两组越期率等多项临床指标并进行比较。结果 :两组治疗后 ,除丙氨酸氨基转移酶复常时间无差异外 ,其余观察指标均存在显著性差异 ,B组疗效优于A组 (P<0 01)。结论 :临床治疗HFRS ,甘草酸

OBJECTIVE:To compare the clinical effects of two isomates of glycyrrhizic acid on patients with hemorrhagic fever with renal syndrome(HFRS) METHODS:78 patients with HFRS were randomized into two groups:A and B Patients of group A and group B were given α-glycyrrhizic acid(Diammonium Glycyrrhizinate) and β-glycyrrhizic acid(Stronger Neo-Minophagen C) intravenously,respectively The clinical parameters such as rate of phase-skip,etc were observed and compared between two groups RESULTS:The rate of phase-skip in group B was higher than that in group A with significant difference(P<0 01) The differences of other parameters except the time of normalization of alanine aminotransferase were also significantly different between two groups CONCLUSION:The efficacy of β-glycyrrhizic acid is superior to that of α-glycyrrhizic acid in treating patients with HFRS