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天津地区3000份脐血HLA-DR等位基因多态性分析 被引量:15

Analyse on the HLA-DR allele polymorphism of 3000 cord blood units in Tianjin area
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摘要 目的 了解天津地区汉族人群HLA DR位点基因多态性和HLA单倍型特点。方法 采用反向聚合酶链反应 序列特异性寡核苷酸探针 (PCR SSOP)杂交的方法 ,对来源于天津地区汉族产妇的 30 0 0份脐血进行HLA DR位点基因分型 ,对分型结果进行分析 ,并与欧洲白种人、西安汉族人群进行比较。结果 天津地区HLA DR等位基因以DRB1 15最为常见 ,其后依次为DRB1 0 9,DRB1 0 7,DRB1 12和DRB1 0 4。主要单倍型依次为A 0 2 DRB1 0 9,A 0 2 DRB1 15 ,B 13 DRB1 0 7,A 0 2 DRB1 12 ,A 30 DRB1 0 7,B 4 6 DRB1 0 9。DRB1 12和DRB1 0 9在天津地区汉族人群中出现频率明显高于欧洲白种人 ,而DRB1 0 1与DRB1 0 3则明显低于欧洲白种人 ,与西安地区汉族人群比较 ,本资料除DRB1 0 4 ,DRB1 13低以外 ,其余均无显著差异。结论 天津地区汉族人群HLA DR位点等位基因多态性与北方汉族人群 (如西安 )分布相近。 Objective To investigate the gene polymorphism of HLA-DR locus and feature of HLA haplotypes of Han Population in Tianjin area.Methods Reverse PCR-SSOP typing results of HLA-DR alleles of 3000 cord blood units from Han population pregnant women in Tianjin area were compared to those of European Caucasian and the Han populations in Xi’an area.Results DRB1 *15, allele presented the highest frequency,followed by DRB1 *09,DRB1 *07,DRB1 *12,and DRB1 *04.The main haplotypes were A *02-DRB1 *09,A *02-DRB1 *15,B *13-DRB1 *07,A *02-DRB1 *12,A *30-DRB1 *07 and B *46-DRB1 *09 in sequence.The frequencies of DRB1 *12 and DRB1 *09 alleles were significantly higher than in European Caucasian,while the frequencies of DRB1*01 and DRB1 *03 alleles were significantly lower than those in European Caucasian.As compared with that of the Han population in Xi’an,there was not significantly difference except a decrease in frequencies of DRB1 *04 and DRB1 *13 alleles.Conclusions Distribution of the allelic polymorphism of HLA-DR locus was similar to those in northern Han population,such as in Xi’an area,and it was obviously different from those in European Caucasian.
出处 《中国输血杂志》 CAS CSCD 2003年第5期306-308,共3页 Chinese Journal of Blood Transfusion
基金 美国中华医学基金 (CMB) 天津市科委社发基金( 0 0 3 119811)部分资助项目
关键词 脐血/胎血 HLA等位基因 基因多态性 基因分型 cord blood,HLA,human gene polymorphism,genotyping
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  • 1赖淑苹,任惠民,胡海涛,李生斌,赖江华,闫春霞,张洪波,赵均海.中国西北地区汉、回、维、藏民族HLA-DRB基因多态性的研究[J].Acta Genetica Sinica,1999,26(5):447-457. 被引量:44
  • 2赵桐茂 步坤距 顾文娟等.HLA抗原在汉族人中的分布调查[J].中华血液学杂志,1981,2(2):99-99.
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