氯沙坦联合依那普利治疗高血压逆转左室肥厚的临床观察

The clinial observation of Losartan in combination with enalapril in treating hypertension and reversing left ventricular hypertrophy

目的 观察氯沙坦联合依那普利治疗高血压逆转左室肥厚的疗效。方法 84例高血压左室肥厚 (LVH)随机分为治疗组 (45例 )和对照组 (39例 )。治疗组给予氯沙坦联合依那普利治疗 ,对照组单用依那普利治疗 ,观察6个月。治疗前后分别测血压、室间隔厚度 (LVST)、左室后壁厚度 (PWT)、左室舒张末期内径 (LVDd)、E、A、E/A ,计算左室重量指数 (LVMI)。结果 两组血压均明显下降 ,组间比较治疗组LVST、PWT、LVMI、LVDd及E/A优于对照组。结论 氯沙坦联合依那普利在有效降压的同时 ,能更有效地逆转LVH ,改善左室舒张功能。

Objective: To evaluate the clinical therapeautic efficacy of Losartan in combination with Enalapril in treating hypertension and reversing left ventricular hypertrophy (LVH). Methods: Eighty-four hypertension patients with LVH were divided randomly into Losartan in combination with Enalapril treatment group(n=45) and 6 months Enalapril control group (n=39),The clinical efficacy, blood pressure, IVST, PWT, LVMI, LVDd and E, A, E/A were observed before and after the treatment. Results: The blood pressure of the twogroups decreased significantly. LVST, PWT, LVMI, LVDd, E, A and E/A were much improved in the treatment group compared with those in the control group. Conclusion: Losartan in combination with Enalapril can significantly decrease blood pressure and is more effective than Enalapril alone in reversing LVH and improving left ventricular diastolic function.