检测脑脊液诊断结核性和病毒性脑膜炎

Detection of PPD-IgG?ADA?and CSF-blood glucose ratio for differential diagnosis of tuberculosis and viral meningitis

目的 研究脑脊液 (CSF)结核抗体 (PPD IgG)、腺苷脱氨酶 (ADA)、脑脊液糖与血糖比值在鉴别诊断结核性与病毒性脑膜炎方面的应用价值。方法 对 15 6例结核性脑膜炎 ,4 2例病毒性脑膜炎患者脑脊液PPD IgG、ADA、脑脊液糖与血糖比值的检测结果进行回顾性对比研究。结果 脑脊液PPD IgG、ADA、脑脊液糖与血糖比值三者对诊断结核性脑膜炎的敏感性分别为 84 6 % (132 / 15 6 )、95 5 % (14 9/ 15 6 )、97 4 % (15 2 / 15 6 ) ;特异性分别为10 0 %、71 4 %和 92 9%。结论 脑脊液PPD IgG、ADA。

Objective: To study the applied value of PPD IgG?ADA in CSF and CSF blood glucose ratio for differential diagnosis of tuberculosis and viral meningitis. Methods:156 patients with tuberculosis and 42 patients with viral meningitis were analyzed respectively.The PPD IgG?ADA of CSF and CSF blood glucose ratio were compared respectively. Result: The sensitivities of PPD IgG, ADA in CSF and CSF blood glucose ratio for diagnosis of tuberculosis meningitis were respectively 84 6%(132/156), 95 5%(149/156) and 97 4%(152/156).The specificities of them were respectively 100%, 71 4% and 92 9%. Conclusion: The PPD IgG, ADA in CSF and CSF blood glucose ratio are good indexes for differential diagnosis of tuberculosis and viral meningitis.