家犬经三氧化二砷(As_2O_3)液温热保留灌肠后毒副作用的观察

Observation of the toxic and side effects after hyperthermal retention enema with arsenic trioxide in dogs

目的 :观察家犬经三氧化二砷液高温保留灌肠后的毒副反应。方法 :将 0 . 1%三氧化二砷液分别在高温 (44℃～ 4 6℃ )和室温 (15℃～ 2 5℃ )下给家犬保留灌肠 ,1次 /d ,每次保留 30min ,连续 7d。然后观察家犬的白细胞增生情况 ,肝肾功能改变 ,食欲 ,精神状态 ,胃肠道反应及直肠粘膜的形态学改变。结果 :在室温和高温As2 O3 液保留灌肠后 ,两组动物白细胞增生不明显 ,肝、肾功能无明显改变 ,食欲无改变 ,精神状态良好 ,无呕吐、腹泻 ,直肠粘膜活检未见病理性损害。结论 :0 . 1%As2 O3 液温热保留灌肠短期内对机体无明显毒副反应。

Objective:To observe the toxic and side action of hyperthermal enema with arsenic trioxide(As 2O 3)in dogs.Methods:Continuous retention enemas of 0.1% As 2O 3 for 7 days(once per day)were given to dogs at high temperatures(44℃ to 46℃)and room temperatures(15℃ to 25℃),respectively,and As 2O 3 was kept for 30 minutes every day.Then,the proliferation of white blood cells,liver function,renal function,appetite,mental status,gastrointestinal action,and the morphological changes of rectal mucose were measured and recorded.Results:There were no significant differences between two groups in proliferation of white blood cells,liver function,renal function,appetite,and mental status.No vomiting or diarrhea was observed in two groups and biopsy of rectal mucosa showed no significant histopathological changes.Conclusion:There are no significant toxic and side actions of tiyperthermal retention enema with 0.1% As 2O 3 in short times.