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拉米夫定引起HBV基因突变研究进展 被引量:1

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摘要 拉米夫定 (lamivudine)为核苷酸类似物 ,主要用于抗病毒治疗 ,长期使用可引起乙肝病毒基因突变 ,突变主要在聚合酶基因YMDD模序 ,导致耐药病毒株 ,影响临床治疗。目前临床检测突变的手段是建立在PCR技术基础上的方法。
出处 《国外医学(生理病理科学与临床分册)》 2003年第5期447-449,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
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