HMG-CoA还原酶抑制剂与肾小球系膜细胞增殖的分子机制
摘要
羟甲基戊二酰辅酶A(HMG CoA)还原酶抑制剂不但有抑制HMG CoA还原酶、调节血脂水平的作用 ,还能通过抑制肾小球系膜细胞核因子κB(NF κB)、转化生长因子 β(TGF β)、血小板衍化生长因子 (PDGF)、纤维连接蛋白 (FN)等转录因子、细胞因子和基质蛋白的合成与分泌 ,从而抑制肾小球系膜细胞增殖与细胞外基质蛋白沉积。HMG CoA还原酶抑制剂将在预防和治疗终末期肾病方面发挥重要的作用。
出处
《国外医学（生理病理科学与临床分册）》
2003年第5期502-503,共2页
Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
基金
国家自然科学基金 (30 2 6 0 0 37)
参考文献11
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