摘要
目的 观察泰素加顺铂方案治疗非小细胞肺癌的疗效及副作用。方法 2 6例晚期非小细胞肺癌患者应用泰素 135 mg/ m2 ,每日一次 ;顺铂 4 0 mg静滴 ,每日 1~ 3次 ,每 2 1日为一疗程 ,共 2个疗程。结果 PR12例 ,NC 9例 ,PD 5例 ,有效率为 4 6 %。不良反应主要为骨髓抑制、恶心、呕吐、肌肉关节痛及脱发等 ,患者耐受良好。结论 泰素联合顺铂方案治疗非小细胞肺癌疗效较好 ,耐受性好。
Objective To observe the efficacy and the toxicity of non-small cell lung cancer patients treated with taxol plus DDP regimen.Methods Twenty-six cases of cytologically and pathologically confirmed advanced non-small cell lung cancer(NSCLC) patients were treated with chemotherapy using gemcitabine and cisplatin. The treatment session started with Taxol 135mg/M 2 (iv) in days 1, followed by DDP 40mg ivgtt in days 1, 2 and 3. Each cycle lasted for 21 days. All patients had two cycles. Results The overall response rate was 46%, including O CR, 12PR, 9NC, 5PD. The side effects were mainly my leosuppression, nausea and vomiting, myalgia and arthralgia, alopecia. No life threatening severe side effect and allergic reaction occurred in this clinical trial.Conclusion Taxol plus DDP is an effective regimen for non-small cell lung cancer. It shows this regimen is safe and well tolerated.
出处
《临床肺科杂志》
2003年第6期493-494,共2页
Journal of Clinical Pulmonary Medicine
关键词
非小细胞肺癌
化疗
Non-small cell lung cancer Chemotherapy