血栓前体蛋白对心肌缺血性疾病的临床意义

The Clincal Signification of Thrombus Precursor Protein in Myocardial Ischemic Patients

目的:血栓前体蛋白(TpP)为血栓发生早期的特异性标记物。本实验通过监测心肌缺血性疾病患者血浆中TpP的水平,以期为临床诊断和治疗及预后判断提供依据。方法:用酶联免疫法(ELSIA),在450nm波长下比色;D-二聚体(D-D)用免疫比色法。检测13例不稳定性心绞痛(UA)和14例急性心肌梗死(AMI)患者血浆中TpP水平。结果:实验中9例AMI患者TpP水平明显升高(>5μg/ml),UA组病人TpP水平11例小于5μg/ml,另2例大于5 μg/ml。结论:TpP在AMI患者血浆中的水平明显升高,对UA患者病情的发展和鉴别以及AMI患者手术过程中抗凝效果和病人预后有一定的提示价值。

Objective: The thrombus precursor protein(TpP) is special marker found in the early thrombosis statsis. To find out its significance in diagnosis and therapy in myocardial ischemic dieases, we detected TpP and D-Dimer in such patients in serums. Methods: TpP was measured by ELSIA method using 450 run,and D-Dimer was detected by immune-chromatogram method.Both were detected in 13 unstable angina(UA) patients, 14 acute mycar-dial infarction( AMI) and 10 normal persons. Results: The levels of TpP in 9 patients of AMI were beyond 5 μg/ ml,but in 13 UA patients, 11 patients TpP were below 5 μg/ml, while 2 patients TpP were beyond 5 μg/ml. Conclusion: We found that the concentrations of TpP not only rise in the early thrombosis statsis, but also have significations in the developing UA patients or in evaluating the effection of anticoagative therapy of AMI patients.