前臂骨密度及血清IGF-1在2型糖尿病的特点

The Characteristic of Serum IGF-1 and Bone Mineral Density in Type 2 Diabetes Mellitus

观察 2型糖尿病患者不同性别、不同年龄阶段以及肥胖与非肥胖状态下IGF - 1血清浓度及前臂骨密度水平。 2型糖尿病 10 0人 ,ELISA法测定血清IGF - 1浓度 ,双能X光骨密度检测仪 (DXA)测量前臂超远端及远端 1/ 3交界处骨密度、骨矿含量及T积分。结果表明 ,骨质疏松症的发病率为 14% ( <5 0岁组 )到 73 % ( >70岁组 ) ,总发病率为 3 3 % (超远端 )和2 7% (远端 )。其中女性发病率为 47.7%和 2 2 .7% ,男性为 2 1.4%和 3 0 .4%。BMD、BMC、IGF - 1血清水平随增龄逐渐低降 ,5 0岁以后女性BMD、BMC较男性显著下降。肥胖者的BMD、BMC较非肥胖者高 ,骨质疏松症的发生率低。IGF - 1在男性与女性之间及肥胖与非肥胖者之间均无差异。 2型糖尿病患者骨质疏松症的发病率女性高于男性 ,非肥胖者高于肥胖者 ,IGF- 1、年龄、体重、雌激素是影响骨代谢的相关因素 ,IGF - 1与年龄和体重无关。男性前臂中远端骨质疏松明显 。

To observe the serum levels of IGF-1 and the bone mineral density of forearm as well as their relationship with age, sex and BMI in type 2 diabetes mellitus, in 100 objects, fasting serum concentrations of IGF-1 were detected by ELISA, and BMD, BMC and T score of ultra-distal, distal of forearm were measured by MEDILINK Dual Emission X-ray Absorptiometry(DEXA).Results showed that the total incidence of osteoporsis was 33%(ultra-distal) and 27%(distal) in 100 type 2 diabetes objects, which was form 14%(<50 years group) to 73%(>70 years group). The incidence of osteoporsis in female were 47.7%(ultra-distal) and 22.7%(distal), while in male were 21.4% and 30.4%. BMD, BMC and serum IGF-1 concentrations gradually reduced with ageing. BMD and BMC reduced obviously after 50 years old in female than in male but they were higher, while the incidence of osteoporsis was lower,in fat group than in non-fat group. There was no difference in serum IGF-1 concentrations between male and female, fat group and non-fat group.In type 2 diabetes mellitus, the incidence of ultra-distal osteoporsis is higher in female than in male, in non-fat group than in fat group. The related factors with bone metabolism are IGF-1, age, weight, estrogens and so on. IGF-1 has no relation with age and weight. Osteoporsis in ultra-distal shows sever in male while light in female.