胆囊结石患者血清结合胆汁酸分析及临床应用

Analysis and Clinical Application of serum conjugated bile acids in cholecystolithiasis

观察胆囊结石患者血清结合型胆汁酸变化情况 ,探讨结合胆汁酸在临床诊断中的应用。采用反相高效液相色谱法 ,对胆囊结石、结石性胆囊炎和胆总管结石患者血清中六种结合胆汁酸进行测定。三种类型胆囊结石病人血清结合胆汁酸普遍高于对照组。胆囊结石组和结石性胆囊炎组除牛磺胆酸比对照组降低外 ,甘氨胆酸、甘氨脱氧胆酸显著升高。胆总管结石组虽各组分变化不明显 ,但各组分之和仍高于对照组。血清结合胆汁酸各组分在诊断胆囊结石 ,了解和预测结石形成中具有重要作用。

WT5”BZ]To observe the change of serum conjugated bile acids in patients suffering from cholecystolithiasis and to discuss the application of conjugated bile acids levels in clinical diagnosis Determination of six conjugated bile acids of patients with bile bladder stone (group one),cholecystitis with the bile stone (group two) and choledocholithiasis (group three)by reverse phase HPLC Results:The levels of six conjugated bile acids in three groups are higher than those in control group For group one and two,GCA and GDCA are significantly higher than those of control but TCA is lower For group three,although the changes of all the observed conjugation bile acids have no statistical significance,the total bile acid level is higher than that of control Conclusion:The bile acid compositions play important roles in diagnosis of bile stone [WT5”HZ]