Cu、Zn、Pb、Cd对鲫鱼(Carassius auratus)组织DNA毒性的研究

TOXICITY OF COPPER, ZINC, LEAD, CADIMUM TO TISSUE’S CELLUR DNA OF THE FISH ( Carassius auratus )

用非程序DNA的合成作为毒性评价指标研究了混合重金属对鲫鱼 (carassiusauratus)组织DNA的毒性作用 ,结果表明 ,混合重金属的毒性作用靶标器官是鱼脑和鱼的肝脏 ;混合重金属中的主要毒性成分是Zn、Pb和Cd离子 ,混合重金属对鱼脑组织的毒性大小顺序是Pb>Cd >Zn ,对肝脏DNA的毒性顺序为Pb >Zn >Cd;Cu离子能够降低其它 3种离子的毒性作用 ,降低的机制在于竞争作用 。

The toxicity of the mixture metals to tissue's cellur DNA of the fish( Carassius auratus ) was studied by the unscheduled DNA synthesis(UDS) method. The results demonstrated that the target organ for the mixture metals was the brain and liver. The key toxicity components in the mixture metals is zinc, lead, cadimum, the magnitude sequence of the toxicity of the components was Pb>Zn Cd in the liver, that sequence in the brian was Pb>Cd>Zn. Copper could decrease the other metlas toxicity as there was the competition between the copper and the other metals, which lead to the decrease uptake of the other metals.