慢性肾功能不全不同损害期患者血清脂蛋白(α)水平的检测及血液透析对其水平的影响

Serum levels of lipoprotein(α) in patients with chronic renal failure an d the effects of hemodialysis on its level s

目的 :观察慢性肾功能不全 (CRI)不同损害期患者血清脂蛋白 (α) [L p(α) ]水平和临床意义以及血液透析 (HD)对其水平的影响。方法 :采用单克隆抗体浊度法测定了 2 2 9例 CRI患者和 96例健康人的血清 (Lp(α)水平 ;对肾功能损害不同期的 Lp(α)水平作比较 ,并与血肌酐 (Scr)水平做相关分析 ;比较非 HD组及维持 HD组的 L p(α)水平。结果 :CRI患者肾功能衰竭期、尿毒症期 L p(α)水平显著高于正常对照组 (分别为 P<0 .0 1 ,P<0 .0 0 1 ) ,血清 Lp(α)水平与 Scr呈中度正相关 (r=0 .54,P<0 .0 1 ) ,HD组较非 HD组 Lp(α)水平增高明显 ,差异有显著性 (P<0 .0 1 )。结论 :CRF患者随着肾功能损害的加重 ,血清 Lp(α)水平增高 ,HD可使其进一步增高。

Objective: To s tudy th e serum levels of Lipoprotein(α) [Lp(α)] in patients with chronic renal insu fficiency (CRI) and the effects of h emodialysis(HD) on its levels Methods: Serum levels of Lp(α) in 229 with CRI patients including various phas es and 96 healthy control were detec ted by means of monoclonal antibodie s method Results: Serum levels of Lp (α) in groups of renal failure phase and uremia were significantly highe r than those in control group ( P <0 0 1 and P <0 001,respectively),There wa s positive correlation between Lp(α) and Scr(r=0 54 P <0 01),and HD group were significantly higher than thos e in non HD group( P <0 01) Conclusion:Serum levels of Lp(α) were heightene d along with renal damaging aggravat ion,furthermore,HD can make them mor e higher