异环磷酰胺为主联合化疗治疗晚期肺癌

Ifosfamide and Chemotherapy-combined Treatment for Advanced Lung Cancer

目的 :观察以异环磷酰胺 (IFO)为主的联合化疗方案治疗晚期肺癌的近期疗效和毒性。方法 :10 3例晚期肺癌 ,随机分为三组分别给予以IFO为主的联合化疗方案IAP、IEP、IVP治疗 ,每 2 1～ 2 8d为一周期。结果 :IAP组 ,IEP组和IVP组有效率分别为 6 2 .5 % ,6 2 .9%和 6 5 .9%。主要毒性反应为骨髓抑制。结论 :以IFO为主的联合化疗治疗晚期肺癌有效率高 ,在G -CSF支持下 。

Objective To observe the short-term effectiveness and toxicity of ifosfamide and chemotherapy-combination treatment for advanced lung cancer. Methods 103 patients with advanced lung cancer were randomly divided into three groups undertaking a combined treatment of IAP,IEP and IVP respectively, the treatment having 21～28 days as a period. Results Total effective rates of IAP,IEP and IVP was 62.5%, 62.9% and 65.9% respectively. The chief toxic reaction was myelosuppression. Conclusions This regimen in question is one of the most effective treatments for advanced lung cancer,and myelosuppression is well toloerated under G-CSF.