妊高症与钙及甲状旁腺素关系的研究

Study on the Relationship between Pregnancy Induced Hypertension and Calcium,Parathyroid Hormone

目的 :探讨钙及甲状旁腺素 (ParathyroidHormone ,PTH)在妊高症发病中的作用。方法 :选择孕周为 2 0～ 2 6周的健康孕妇 ,分为二组 ,补钙组 93例 ;对照组 6 7例 ,于孕中期及孕晚期分别测定血清钙、磷、PTH。结果 :与正常孕妇相比 ,妊高症患者低血钙 ,高血磷、PTH升高 ,补钙组妊高症发病率 (3.2 3% )低于对照组 (13.43% )。结论 :低血钙与PTH分泌增加有关 ,钙离子跨膜内流和激活腺苷酸环化酶 ,致胞浆内钙离子浓度升高 ,引起血压升高。

Objective To study the relationship between pregnancy induced hypertension (PIH) and calcium,parathyroid hormone (PTH).Methods Healthy pregnant women of 20～26 gestational weeks were divided into two groups:one group of 93 cases supplemented with calcium and the other group of 67 cases (control group),and their serum calcium,phosphorus and PTH were determined at the time of midtrimester of pregnancy and late pregnancy respectively.Result Compared with normal pregnancy,patients of PIH showed hypocalcemia,hyperphospheremia and PTH elevation.The PIH incidence (3.23%) of the calcium group was lower than that of the control group (13.43%).Conclusion Hypocalcemia makes PTH secretion increase,calcium ion transmembrane flow in and adenylate cyclase activate.The concentration of the intracytoplasmic-calcium-ion elevates,which also cause blood pressure elevation.It is important for the pregnancy women to have calcium supplement to prevent PIH.