摘要
目的 :探讨高钠盐引发的高血压发病机制。方法 :雄性SD大鼠 4 0只 ,分为对照 (NC)组、高盐 (HS)组、高盐 +L -精氨酸 (HS +Arg)组、高盐 +依那普利 (HS +En)组和高盐 +特拉唑嗪 (HS +Ter)组 ,每组 8只。各组饲料相同。NC组饮去离子水 ;HS组饮 1 5 %氯化钠溶液 ;HS +Arg组、HS +En组和HS +Ter组分别饮用 1 5 %氯化钠溶液配制的L -精氨酸 ( 4g·kg-1·d-1)、依那普利 ( 3 0mg·kg-1·d-1)和盐酸特拉唑嗪 ( 4mg·kg-1·d-1)。第 8周末 ,大鼠在戊巴比妥钠麻醉下 ,直接测量颈总动脉血压 ,开腹抽取下腔静脉血及剖取肾脏、肾上腺。测定前海葱苷原A样物质 (PLC)水平 ,Na+ K+ ATP酶活性 ,NO(x)、内皮素 (ET)及血管紧张素II(AngII)水平。结果 :HS组大鼠血压显著高于NC组 ,血浆PLC、ET及肾上腺AngII水平皆显著高于NC组 ;血浆和肾组织NO(x)和AngII水平、肾脏Na+ K+ ATP酶活性皆明显低于NC组 ;HS +Arg组、HS +En组和HS +Ter组大鼠血压和血浆PLC水平皆显著低于HS组 ,血浆和肾组织NO(x)水平及Na+ K+ ATP酶活性皆明显高于HS组 ;HS +Arg组、HS +En组和HS +Ter组肾上腺AngII水平及HS +Arg组血浆ET水平明显低于HS组 ,并与NC组相近。结论 :在高钠盐引发的高血压发病机制中 ,除钠泵抑制因子释放增加致细胞膜Na+ K+ ATP酶活性?
AIM: To reveal the pathogenesis of salt-induced hypertension. METHODS: Forty male SD rats were divided into five groups, which received on same chow but different drink. Control(NC)group: deionized water; High salt(HS)group: 1.5% NaCl solution; L-arginine(HS+Arg)group: L-arginine(4 g·kg -1 ·d -1 )in 1.5% NaCl solution; Enalapril (HS+En) group: enalapril (30 mg·kg -1 ·d -1 ) in 1.5% NaCl solution; Terazozin(HS+Ter)group: terazozin(4 mg·kg -1 ·d -1 )in 1.5% NaCl solution. At the end of 8 weeks, rats were anesthetized with pentobarbital sodium. Blood pressure(BP)were recorded and blood were drawn from inferior vena cava and kidneys, adrenals were removed. NO(x),ET and AngII, Na + K + ATPase and proscillaridin-like compound(PLC)were assayed. RESULTS: BP, PLC and ET in plasma and AngII in adrenal were increased, NO(x)and AngII in plasma and kidney were decreased in HS group compared with NC group. CONCLUSION: High salt intake may induce hypertension in SD rats. In addition to the Na + K + ATPase activity was inhibited by increased sodium-pump inhibitors, NO release decrease may also play an important role in the pathogenesis of hypertension.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2001年第2期143-146,共4页
Chinese Journal of Pathophysiology
基金
河北省自然科学基金资助项目 (No .3 993 91)
关键词
氯化钠
钠
膳食
腺苷三磷酸酶
钠
钾
一氧化氮
高血压
Sodium chloride
Sodium, dietary
Adenosine triphosphatase, sodium, potassium
Nitric oxide
Hypertension