摘要
目的 探讨胺碘酮对慢性持续性房颤病人心室反应昼夜节律的影响．方法 进择６８例４１～７７岁的房颤病人接受小剂量胺碘酮的治疗，胺碘酮剂量从 ２００ ｍｇ ／ｄ开始，１周后改为 １００ ｍｇ ／ｄ继续治疗 ２周，用药前后行动态心电图检查，观察病人心室反应节律的昼夜分布特征．结果 发现房颤病人心室反应有其一定的昼夜节律，在凌晨 ４时至 ５时达谷值、于上午 １０时至１１时达峰值。应用胺碘酮后，２４ ｈ总心室率、最快心率及２４ ｈ平均心率均有所下降，但其心室反应的昼夜特征无改变．结论 胺碘酮可有效控制房颤病人的心室率，而对其心室反应的昼夜节律无显著影响．
Objective To investigate the effect of amiodarone on diurnal distribution of ventricular response in patients with atrial fibrillafion(AF). Methods Totally 68 patients aged 41-72 years old with AF were given low dose amiodarone orally. The initial dose was 200mg/d, after one week, the dosage was diminished to l00mg/d, the treatment duration was three weeks, hotler monitoring was used to assess the characteristic of diurnal distribution of ventricular respones before and after treatment. Results The diurnal distribution of ventricular response in patients with AF showed a regular cireadian variation,the trough of heart rate were from 4Am to 5Am and peak from l0Am to 11Am. The amiodarone decreased the total heart rate Maximum heart rate and 24 hour average heart rate of AF, but did not change the characteristic of circadian variation of ventricular response. Conclusion The amiodarone is effective and safe to slow down ventricular response of AF. There was no relationship between low dose amiodarone and circadian variation of ventricular response.
