诺森(注射用泮托拉唑钠)治疗上消化道出血疗效观察

Observation of the Therapeutic Effect of Pantoprazole on Hemorrhage of Upper Digestive Tract

目的:验证与评估诺森(注射用泮托拉唑钠)治疗上消化道出血的临床疗效和安全性。方法:采用随机分组、平行对照、多中心同步试验方法,对160例各种类型胃炎、消化性溃疡、肝硬化合并胃粘膜病变所致上消化道出血患者,分别应用诺森针剂40mg,qd,静滴3d～5d;奥美拉唑40mg,qd,静滴3d～4d,观察两组药物止血效果及不良反应。结果:诺森组与奥美拉唑组总有效率分别为96.67％与95.00％,两组间疗效无显著性差异(P>0.05);不良反应发生率分别为6.67％和6.67％,两组间无显著性差异(P>0.05),且不良反应轻微;两组病人用药前后造血功能和肝、肾功能及尿常规均无显著性变化。结论:诺森治疗上消化道出血具有较好的疗效,且无明显不良反应。

OBJECTIVE:To verify and evaluate the effect and safety of pantoprazole in treating hemorrhage of upper digestive tract. METHODS:Using randomized group sampling,paired control and multicenter study,the hemostatic effects and adverse reactions of pantoprazole(PZ)and omeprazole (OZ) were observed in 160 cases who received PZ(40mg im qd and iv 3-5 days) or OZ (40mg im qd and iv 3-4 days) .RESULTS: The effective rates of PZ and OZ group were 96.67% and 95.00% respectively without difference between two groups(P>0.05) .The rates of ARDs of PZ and OZ group were 6.67% and 6.67% respectively without difference between two groups. The ARDs were mild.There were no significant changes of hematopoietic, hepatic and renal functions and routine urine examination in both groups after treatment .CONCLUSION: PZ shows satisfactory therapeutic effect on hemorrhage of upper digestive tract and no marked ARDs.It is worth extending and applying.