肝硬化食管静脉曲张破裂出血患者善宁治疗前、后血清血管紧张素转换酶水平的变化

Changes of the Concentration of Serum Angiotension I Converting Enzyme in Patients With Liver Cirrhosis Complicated With Esophageal Varices Hemorrhage Before and After Sandostatin Therapy

目的:探讨肝硬化食管静脉曲张破裂出血患者善宁应用与血清血管紧张素转换酶(ACE)水平变化的关系。方法:采用紫外光度比色分析法测定40例肝硬化食管静脉曲张破裂出血患者善宁治疗前、后及20例健康对照者血清ACE浓度。结果:肝硬化食管静脉曲张破裂出血患者善宁治疗前、后血清ACE浓度均明显高于对照组。食管静脉曲张破裂出血患者善宁治疗前血清ACE浓度明显高于治疗72小时后的水平。结论:善宁治疗可使肝硬化食管静脉曲张破裂出血患者血清ACE水平下降,这可能与善宁降低门静脉压力的机制有关。

OBJECTIVE:To investigate the relation between the sandostatin therapy and the changes of serum angiotensin I converting enzyme(ACE) in the patients with liver cirrhosis complicated with esophageal varices hemorrhage.METHODS: Serum ACE was measured by UV - spectrocolorimetry in 40 cases of liver cirrhosis with esophageal varices hemorrhage before and after sandostatin therapy and 20 healthy controls.RESULTS: The levels of serurn ACE both pre - and post - sandostatin therapy in the patients with liver cirrhosis complicated with esophageal varices hemorrhage were markedly higher than that of healthy controls.The serum ACE level in patients with liver cirrhosis before treatment was significantly higher than that 72 hours after treatment .CONCLUSION: Sandostatin, in the patients with liver cirrhosis complicated with esophageal varices hemorrhage, can make the concentration of serum ACE decrease, which is probably associated with the mechanism of sandostatin in lowering the portal venous pressure.