洛赛克治疗急性脑血管病并发应激性溃疡出血的疗效观察

Observation of the Therapeutic Effect of Losec on Bleeding of Stress Ulcer Complication Acute Cere-brovascular Diseases

目的:观察洛赛克治疗急性脑血管病并发应激性溃疡出血的疗效。方法:58例急性脑血管病并发应激性溃疡出血患者随机分成研究组(30例)和对照组(28例),两组基础治疗相同。研究组给予洛赛克40mg,静脉注射,qd,连用5天;对照组应用西米替丁800mg,静脉滴注,qd,连用5天。结果:研究组显效率为60.00％,总有效率为93.33％,明显高于对照组(分别为14.29％和60.71％,P<0.01);平均止血时间为(45.8±1.9)小时,明显短于对照组(82.5±2.8)小时(P<0.01)。结论:洛赛克是治疗急性脑血管病并发应激性溃疡出血安全而有效的药物。

OBJECTIVE: To observe the efficacy and safety of Losec in the treatment of bleeding of stress ulcer complicating acute cerebrovascular diseases.METHODS: 58 patients with stress ulcer bleeding complicating acute cerebrova.scular disease were randomly devided into study group(30 cases) and control group(28 cases) .The study group received Losec 40mg/d iv drip for 5 days, and the control group Cimitidine 800mg/d iv drip for 5 days.RESULTS:The effective rate and the total effective rate of the study group were 60.00% and 93.33% and those of the control group were 14.29% and 60.71% (P<0.01), respectively. The mean hemostatic time of the study group((45.8±1.9) h) was shorter than that of the control group((82.5± 2.8) h) (P<0.01) .CONCLUSION: Losec is a safe and effective drug for treating the patients with stress ulcer bleeding complicating acute cerebrovascular disease.