急性冠状动脉综合征患者血管紧张素转换酶基因插入/缺失多态性分析

Analysis of the Insertion/Deletion Polymorphism of Angiotension Converting Enzyme Gene in Acute Coronary Syn- drome.

目的 以急性冠脉综合征(ACS)患者为研究对象,探讨ACE基因插入/缺失(I/D)多态性在其发病中的作用.方法 利用多聚酶反应(PCR)方法对169例急性冠脉综合征(ACS)患者及94例正常健康人的血管紧张素转换酶(ACE)基因插入/缺失多态性变异进行对比分析.结果 ACS患者ACE基因DD型及D等位基因频率明显高于对照组(DD,0.385:0.213;D,0.583:0.441),而且ACE基因各型间其它冠心病危险因素比较无统计学差异.结论在国人中ACE基因DD型可能是ACS发病的独立因素.

Objective:The present study was performed to investigate the correlation between ACE genetic polymorphism and acute coronary syndrome by comparing the distribution of ACE genotypes and alleles in patients with a-cute MI and unstable angina with those in control. Methods:The genotype of ACE gene was detected by PCR. Results : The frequency of genotype DD and D allele were significantly higher in patients with acute coronary syndrome than in controls(0. 385 vs 0. 213,0. 583 vs 0. 441 ,respectively). There were no differences among the three genotypes in the other risk factors for coronary artery diseases. Conclusion:The ACE gene I/D polymorphism is an independent risk factor for acute coronary syndrome in Chinese.