血小板膜流动性与急性心肌梗死关系的临床研究

Clinical research of relationship between platelet membrane fluidity and acute myocardial infarction

目的 探讨血小板膜流动性在急性心肌梗死(AMI)时的改变特点及与病情程度的相关性.方法 采用以DPH(二苯乙三烯)为探针的荧光偏振法测定53例正常人和28例AMI患者在发病第一、二、三、七及十四天的血小板膜流动性.结果 AMI患者第一、二天血小板膜流动性明显低于正常对照组,差异有显著性(P<0.05,P<0.01),AMI患者发生严重并发症时血小板膜流动性降低更明显.结论 AMI患者确有血小板膜流动性的动态变化,血小板膜流动性的改变对早期判断及反映AMI的病情程度有一定意义.

Objective To investigate the relationship between platelet membrane fluidity and acute myocardial infarction. Methods We detected platelet membrane fluidity of 53 health volunteers and 28 patients in 1st ,2nd ,3rd ,7th and 14th day of acute myocardial infarction by fluoresscence palarization technology. Results The levels of platelet membrane fluidity were significantly lower in 1st and 2nd day of acute myocardial infarction than controls (P<0. 05. P< 0. 01). Severe complications in acute myocardial infarction had significantly reduced platelet membrane fluidity. Conclusion We find that there was change of platelet membrane fluidity in acute myocardial infarction. These results indicate that platelet membrane fluidity play a role in estimate early stage and severe degree of acute myocardial infarction.