急性冠状动脉综合征低/高危人群血管紧张素转换酶基因插入/缺失多态性分析

Analysis of the Insertion/Deletion Polymorphism of Angiotension Converting Enzyme Gene in Low/High-risk Group in Acute Coronary Syndrome

目的 探讨ACE基因插入/缺失(I/D)多态性在急性冠状动脉综合征低/高危人群发病中的作用.方法 根据apoB、BMI将169例急性冠状动脉综合征(ACS)患者及94例正常健康人分为低危和高危人群,利用多聚酶反应(PCR)方法对这些患者的血管紧张素转换酶(ACE)基因插入/缺失多态性变异进行对比分析.结果ACS患者ACE基因DD型及D等位基因频率明显高于对照组(DD,0.385:0.213.P<0.05;D,0.583:0.441,P<O.01),在低危人群中ACS组DD基因型和D等位基因频率较对照组升高(DD,0.444:0.227,P<0.05;D,0.62:0.432,P<0.01).而在高危人群中,虽然病例组基因频率高于对照组,但无统计学意义.结论 在中国汉族人群中ACE基因I/D多态性是ACS发病的一个独立的危险因素,尤其在低危人群中意义更大.

Objective The present study was performed to investigate the correlation between ACE genetic polymorphism and Low/High-risk Group in acute coronary syndrome. Methods Accoding to serum apoB and BMI, we divided 169 ACS patients and 94 normal people into low (apoB<0. 83g/1, BMI<23. 12kg/m ) and high risk group. The genotype of ACE gene was detected by PCR. Results The ferquency of genotype DD and Dallele were significantly higher in patients with acute coronary syndrome than in controls (0. 385 vs 0. 213, 0. 583 vs 0. 441. respectively). In low-risk group, the association between the ACE I/D polymorphism and acute coronary syndrome was high significant ( 0. 444 vs 0. 227, P<0. 05 ;0. 625 vs 0. 432, P<0. 01). Conversely, there were no differences in high-risk group. Conclusion: The ACE gene I/D polymorphism is an independent risk factor for acute coronary syndrome in Chinese population,especially low-risk group.