前列腺素合并应用丹那唑终止早孕的临床研究

A Clinical Study of Termination of Early Pregnancy by Administration of Prostaglandin in Combination with Danazol

15-甲基前列腺素F_(2α)合并丹那唑或丙酸睾丸酮抗早孕(≤49天)共105例,其中前者66例,完全流产率93.94%而后者39例作为对照,完全流产率为82.05%,两者有显著差异(P<0.05)。丹那唑是阴道给药,无副反应,对肝、肾与心脏无影响。因此,用此药合并前列腺素抗早孕值得进一步探索。

Early pregnancy (≤49d), 105 cases, were terminated by 15-methyl prostaglandin F_(2α) (PGF_(2α)) combined with danazol or testosterone propionate. Among them, 66 cases falling in the former group attained a complete abortion rate of 93.94%, and 39 eases in the latter group, had the rate of 82.05%, showing a difference statistically significant (P<0.05). Danazol was administered by patients themselves through vaginal mute. No side effects, particularly those to the heart, liver and kidneys, were noticed. Its therapeutic effect was comparable to that of Ru486 (mifepristone) used in combination with prostaglandin for the same purpose. Besides, danazol was much cheaper than Ru486. Thus, this approach is worthy for further clinical therapeutic trial.