金龙胶囊对局部肿瘤切除前后不同时间施药抑制术后复发及转移的研究

The Effect of Jin Long Capsule on recurrent and Metastatic tumor cells before and after Local Resection of Primary Tumor

目的：研究JLC对小鼠宫颈癌（U14）移植后，手术切除局部原发瘤之前、后用药，观察抑制肿瘤术后局部复发和术后转移的作用。方法：以小鼠宫颈癌（U14）双向高转移模型为对象，以JLC在肿瘤切除前5天和后5天两组用药进行对比，又以相同分组的环磷酰胺化疗进行了比较观察。结果：1）环磷酰胺对U14的局部复发及复发转移均有明显抑制作用，术前组抑瘤率为93．7％，转移抑制率为55．7％；术后组抑瘤率为35．1％，转移抑制率为34．1％；术前组肺转移抑制率为100．0％。2）JLC对U14的局部复发和复发转移均有明显抑制作用，术前组抑瘤率为67．3％；转移抑制率为47．6％；术后组抑瘤率为73．0％，转移抑制率为42．3％；术前组肺转移抑制率为86．5％。无论术前或术后组肺转移抑制率均高于淋巴结转移。结论：金龙胶囊对术后复发转移抑制作用，术前用药优于术后用药。局部抑瘤率均在60．0％以上，转移抑制率均在40．0％以上。因此JLC在手术前和手术后给药均可抑制局部复发和复发转移。提示手术时合并使用JLC是较为理想的治疗方案。

Objective To observe the effects of Jin Long Capsule JLC on recurrence and metastasis of murine cervical carcinoma U14 before and after resection of primary tumor． Methods Highly metastatic both lymph node and lung murine cervical carcinoma was implanted． The primary tumor was resected on the 10th day． JLC was given orally starting 5 days before group Ⅰ and after group Ⅱ operation． The curative effects of Cyclophosphamide treatment in both groups were comparatively observed． Results 1 When Cyclophosphamide treatment started 5 days before operation the recurrent tumor inhibition rate and the metastatic tumor inhibition rate were 97．3％ and 55．7％ respectively and those for the groups 5 days after operation were 35．1％ and 34．1％ respectively． The lung metastatsis inhibition rate was 100％ in the group received treatment 5 days before operation． 2 The inhibitory effect of JLC on recurrent and metastatic tumors were obvious． The inhibition rate of recurrent tumor and metastatic tumor were 67．3％ and 47．6％ respectively for group Ⅰ． The groups Ⅱ were 73％ and 86．5％ respectivdely． The inhibition rate for lung metastasis was 86．5％ for group Ⅰ． JLC showed a better inhibition effect on lung metastasis than that on lymph node metastasis． Conclusion JLC displays an inhibitory effect on recurrence and metastasis of tumor after local resection． It is more beneficial to administrate JLC before operation than after it． Whenever JLC is used the inhibition rate of local recurrence is more than 60％ and that of metastasis is more than 40％． Therefore JLC is an effective agent for recurrence and metastasis of tumor． Clinically JLC can be used for cancer therapy in combination with surgical resection．